DNA methylation gene-based models indicating independent poor outcome in prostate cancer.

ABSTRACT:

Background

Prostate cancer has a variable clinical behaviour with frequently unpredictable outcome. DNA methylation plays an important role in determining the biology of cancer but prognostic information is scanty. We assessed the potential of gene-specific DNA methylation changes to predict death from prostate cancer in a cohort of untreated men in the UK.

Methods

This was a population-based study in which cases were identified from six cancer registries in Great Britain. DNA was extracted from formalin-fixed paraffin wax-embedded transurethral prostate resection tissues collected during 1990-96 from men with clinically-localised cancer who chose not to be treated for at least 6 months following diagnosis. The primary end point was death from prostate cancer. Outcomes were

SUBMITTER: Vasiljevic N 

PROVIDER: S-EPMC4162944 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature