Transcriptional profiles of bovine in vivo pre-implantation development.

ABSTRACT:

Background

During mammalian pre-implantation embryonic development dramatic and orchestrated changes occur in gene transcription. The identification of the complete changes has not been possible until the development of the Next Generation Sequencing Technology.

Results

Here we report comprehensive transcriptome dynamics of single matured bovine oocytes and pre-implantation embryos developed in vivo. Surprisingly, more than half of the estimated 22,000 bovine genes, 11,488 to 12,729 involved in more than 100 pathways, is expressed in oocytes and early embryos. Despite the similarity in the total numbers of genes expressed across stages, the nature of the expressed genes is dramatically different. A total of 2,845 genes were differentially expressed among different stages, of

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC4162962 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature