Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome.

ABSTRACT: The effects of interictal epileptiform discharges on neurocognitive development in children with medically-intractable epilepsy are poorly understood. Such discharges may have a deleterious effect on the brain's intrinsic connectivity networks, which reflect the organization of functional networks at rest, and in turn on neurocognitive development. Using a combined functional magnetic resonance imaging-magnetoencephalography approach, we examine the effects of interictal epileptiform discharges on intrinsic connectivity networks and neurocognitive outcome. Functional magnetic resonance imaging was used to determine the location of regions comprising various intrinsic connectivity networks in 26 children (7-17 years), and magnetoencephalography data were reconstructed from these locations.

SUBMITTER: Ibrahim GM 

PROVIDER: S-EPMC4163036 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature