Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line.

ABSTRACT:

Background

The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology.

Results

Here, we have compared gene expression profiles of a human CD4+ T cell line at 24 h after infection with a cell line of the same origin permanently releasing SIVmac. A new knowledge-based-network approach (Inter-Chain-Finder, ICF) has been used to identify sub-networks associated with cell survival of a chronically SIV-infected T cell line. Notably, the method can identify not only differentially expressed key hub genes but also non-differentially expressed, critical, 'hidden' regulators. Six out of the 13 predicted major hidden key regulators were among the landscape of proteins

SUBMITTER: He FQ 

PROVIDER: S-EPMC4163169 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature