Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer.

ABSTRACT: More than half a century from postulated Warburg theory of cancer cells origin, a question of changed metabolism in cancer is again taking the central place. Generalized picture of cancer metabolism was replaced by analysis of signaling and oncogenes in each type of cancer for several decades. However, now empowered with wealth of knowledge about tumor suppressors, oncogenes, and signaling pathways, reprogramming of cellular metabolism (e.g., increased glycolysis to respiration ratio in cancer cells) reemerged as an important element of cancer progression. To analyze level of expression of various proteins including metabolic enzymes across various cancers we used dbEST and Unigene data. We delineated a list of genes that are overexpressed in different types of cancer. We also grouped over

SUBMITTER: Poliakov E 

PROVIDER: S-EPMC4163292 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature