Multiple analytical approaches demonstrate a complex relationship of genetic and nongenetic factors with cisplatin- and carboplatin-induced nephrotoxicity in lung cancer patients.

ABSTRACT:

Background

Cisplatin and carboplatin cause nephrotoxicity by forming platinum-DNA adducts and lead to cell death.

Methods

One-hundred and sixteen Taiwanese lung cancer patients who received cisplatin or carboplatin more than twice were recruited, and their genotypes were determined. The risk of renal dysfunction, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage kidney disease (RIFLE) criteria were used to evaluate the occurrence of nephrotoxicity. A logistic regression, multiple regression with a classification and regression tree (CART), and the Framingham study risk score were used to analyze interactions between genetic and nongenetic factors in producing platinum-induced nephrotoxicity.

Results

ERCC1 118C and TP53 72Arg poly

SUBMITTER: Liu HE 

PROVIDER: S-EPMC4163485 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature