Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.

ABSTRACT:

Objective

Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults.

Design

Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT).

Participants

426 women from WHI older than age 50 years, and 509 men older than age 55 years (age 50 years for African American men) from SELECT.

Measurements

65 candidate gene SNPs that were judged by consensus, based on a literature review

SUBMITTER: Rana BK 

PROVIDER: S-EPMC4163500 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature