The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors.

ABSTRACT:

Objective

Elevated levels of advanced oxidation protein products have been described in several chronic inflammatory diseases, like chronic renal insufficiency, rheumatoid arthritis, and atherosclerosis. Recent findings revealed that advanced oxidation protein products are inhibitors of the major high-density lipoprotein receptor, scavenger receptor class B, type 1 (SR-BI). Here, we investigated which oxidation-induced structural alterations convert plasma albumin into a high-density lipoprotein-receptor inhibitor.

Approach and results

Exposure of albumin to the physiological oxidant, hypochlorous acid, generated high-affinity SR-BI ligands. Protection of albumin-lysine residues before exposure to hypochlorous acid as well as regeneration of N-chloramines after oxidation of

SUBMITTER: Binder V 

PROVIDER: S-EPMC4163628 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature