Ontology highlight
ABSTRACT:
SUBMITTER: Uchil PD
PROVIDER: S-EPMC4163643 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Journal of cell science 20140711 Pt 18
Focal adhesions are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of focal adhesions is crucial for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating focal adhesion dynamics. Here, we identify TRIM15, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal adhesions. TRIM15 localizes to focal contacts in a myosin-II-independent manner by an ...[more]