Lessons learned from a randomized trial of airway secretion clearance techniques in cystic fibrosis.

ABSTRACT:

Rationale

Airway secretion clearance therapies are a cornerstone of cystic fibrosis care, however longitudinal comparative studies are rare. Our objectives were to compare three therapies [postural drainage and percussion: (postural drainage), flutter device (FD), and high frequency chest wall oscillation: (vest)], by studying (1) change in pulmonary function; (2) time to need for intravenous (IV) antibiotics, (3) use of pulmonary therapies, (4) adherence to treatment, (5) treatment satisfaction, and (6) quality of life.

Methods

Participants were randomly assigned to one of three therapies twice daily. Clinical outcomes were assessed quarterly over 3 years.

Results

Enrollment goals were not met, and withdrawal rates were high, especially in postural drainage (51%) and

SUBMITTER: Sontag MK 

PROVIDER: S-EPMC4163837 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature