Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapy.

ABSTRACT: Cell proliferation is a delicately regulated process that couples growth signals and metabolic demands to produce daughter cells. Interestingly, the proliferation of tumor cells immensely depends on glycolysis, the Warburg effect, to ensure a sufficient amount of metabolic flux and bioenergetics for macromolecule synthesis and cell division. This unique metabolic derangement would provide an opportunity for developing cancer therapeutic strategy, particularly when other diverse anti-cancer treatments have been proved ineffective in achieving durable response, largely due to the emergence of resistance. Recent advances in deeper understanding of cancer metabolism usher in new horizons of the next generation strategy for cancer therapy. Here, we discuss the focused review of cancer energy me

SUBMITTER: Kee HJ 

PROVIDER: S-EPMC4163877 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature