Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer.

ABSTRACT:

Background

The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium.

Methods

Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression.

Results

For white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P =

SUBMITTER: Milne RL 

PROVIDER: S-EPMC4164116 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature