Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators.

ABSTRACT:

Background

Periodontitis is an infectious and inflammatory disease of polymicrobial etiology that can lead to the destruction of bones and tissues that support the teeth. The management of chronic periodontitis (CP) relies heavily on elimination or at least control of known pathogenic consortia associated with the disease. Until now, microbial plaque obtained from the subgingival (SubG) sites has been the primary focus for bacterial community analysis using deep sequencing. In addition to the use of SubG plaque, here, we investigated whether plaque obtained from supragingival (SupG) and tongue dorsum sites can serve as alternatives for monitoring CP-associated bacterial biomarkers.

Results

Using SubG, SupG, and tongue plaque DNA from 11 healthy and 13 diseased subjects, we s

SUBMITTER: Galimanas V 

PROVIDER: S-EPMC4164120 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature