Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics.

ABSTRACT: Axonal damage is a prominent cause of disability and yet its pathogenesis is incompletely understood. Using a xenogeneic system, here we define the bioenergetic changes induced in rat neurons by exposure to cerebrospinal fluid samples from patients with multiple sclerosis compared to control subjects. A first discovery cohort of cerebrospinal fluid from 13 patients with multiple sclerosis and 10 control subjects showed that acute exposure to cerebrospinal fluid from patients with multiple sclerosis induced oxidative stress and decreased expression of neuroprotective genes, while increasing expression of genes involved in lipid signalling and in the response to oxidative stress. Protracted exposure of neurons to stress led to neurotoxicity and bioenergetics failure after cerebrospinal fluid

SUBMITTER: Vidaurre OG 

PROVIDER: S-EPMC4164163 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature