Age-related effect of serotonin transporter genotype on amygdala and prefrontal cortex function in adolescence.

ABSTRACT: The S and LG alleles of the serotonin transporter-linked polymorphic region (5-HTTLPR) lower serotonin transporter expression. These low-expressing alleles are linked to increased risk for depression and brain activation patterns found in depression (increased amygdala activation and decreased amygdala-prefrontal cortex connectivity). Paradoxically, serotonin transporter blockade relieves depression symptoms. Rodent models suggest that decreased serotonin transporter in early life produces depression that emerges in adolescence, whereas decreased serotonin transporter that occurs later in development ameliorates depression. However, no brain imaging research has yet investigated the moderating influence of human development on the link between 5-HTTLPR and effect-related brain function. We

SUBMITTER: Wiggins JL 

PROVIDER: S-EPMC4164216 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature