Length of day during early gestation as a predictor of risk for severe retinopathy of prematurity.

ABSTRACT:

Purpose

Fetal mice require light exposure in utero during early gestation for normal vascular development in the eye. Because angiogenic abnormalities in retinopathy of prematurity (ROP) are manifested in preterm infants, we investigated whether day length during early gestation was associated with severe ROP (SROP).

Design

Single-center, retrospective cohort study.

Participants

We included a total of 343 premature infants (401-1250 g birth weight [BW], from 1998-2002): 684 eyes (1 eye each of 2 patients excluded) with 76 eyes developing SROP, defined as (1) classic threshold ROP in zone I or II, (2) type 1 ROP in zone I, or (3) in a few eyes, type 1 ROP in posterior zone II that was treated.

Methods

For each infant, average day length (ADL) was calculated duri

SUBMITTER: Yang MB 

PROVIDER: S-EPMC4164223 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature