Pathways analysis of molecular markers in chronic sinusitis with polyps.

ABSTRACT:

Objective

To perform a comprehensive molecular pathways analysis of genes identified through genome-wide expression profiling and the published literature for chronic sinusitis with polyps.

Study design

Molecular pathways analysis.

Setting

Academic medical center.

Methods

A molecular pathways analysis of gene biomarkers discovered through hypothesis-driven and high-throughput molecular studies was performed. Genes identified with a PubMed literature search were analyzed with Ingenuity Pathways Analysis software to identify central molecules implicated in the pathogenesis of chronic sinusitis with polyps. The central pathways were then compared with those identified through genome-wide expression profiling of ethmoid polyps.

Results

A total of 97 molecule

SUBMITTER: Platt MP 

PROVIDER: S-EPMC4164309 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature