Reproductive windows, genetic loci, and breast cancer risk.

ABSTRACT:

Purpose

The reproductive windows between age at menarche and age at first birth (standardized age at first birth) and from menarche to menopause (reproductive lifespan) may interact with genetic variants in association with breast cancer risk.

Methods

We assessed this hypothesis in 6131 breast cancer cases and 7274 controls who participated in the population-based Collaborative Breast Cancer Study. Risk factor information was collected through telephone interviews, and DNA samples were collected on a subsample (N= 1484 cases, 1307 controls) to genotype for 13 genome-wide association study-identified loci. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and P values for the interaction between reproductive windows and genotypes were obtained by

SUBMITTER: Warren Andersen S 

PROVIDER: S-EPMC4164346 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature