N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles.

ABSTRACT: A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported.

SUBMITTER: Hovey MT 

PROVIDER: S-EPMC4164393 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature