Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.

ABSTRACT: Recent analyses have identified positively selected loci that explain differences in immune responses, body forms, and adaptations to extreme climates, but variants that describe adaptations in energy-balance regulation remain underexplored. To identify variants that confer adaptations in energy-balance regulation, we explored the evolutionary history and functional associations of candidate variants in 207 genes. We screened single nucleotide polymorphisms in genes that had been associated with energy-balance regulation for unusual genetic patterns in human populations, followed by studying associations among selected variants and serum levels of GIP, insulin, and C-peptide in pregnant women after an oral glucose tolerance test. Our analysis indicated that 5' variants in CDKAL1, CYB5R4, G

SUBMITTER: Chang CL 

PROVIDER: S-EPMC4164438 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature