Engineering biodegradable polyester elastomers with antioxidant properties to attenuate oxidative stress in tissues.

ABSTRACT: Oxidative stress plays an important role in the limited biological compatibility of many biomaterials due to inflammation, as well as in various pathologies including atherosclerosis and restenosis as a result of vascular interventions. Engineering antioxidant properties into a material is therefore a potential avenue to improve the biocompatibility of materials, as well as to locally attenuate oxidative stress-related pathologies. Moreover, biodegradable polymers that have antioxidant properties built into their backbone structure have high relative antioxidant content and may provide prolonged, continuous attenuation of oxidative stress while the polymer or its degradation products are present. In this report, we describe the synthesis of poly(1,8-octanediol-co-citrate-co-ascorbate) (POC

SUBMITTER: van Lith R 

PROVIDER: S-EPMC4164534 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature