Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels.

ABSTRACT: Peripheral artery disease (PAD) is characterized by vessel occlusion and ischemia in the limbs. Treatment for PAD with surgical interventions has been showing limited success. Moreover, recent clinical trials with treatment of angiogenic growth factors proved ineffective as increased angiogenesis triggered severe inflammation in a proportionally coupled fashion. Hence, the overarching goal of this research was to address this issue by developing a biomaterial system that enables controlled, dual delivery of pro-angiogenic C16 and anti-inflammatory Ac-SDKP peptides in a minimally-invasive way. To achieve the goal, a peptide-loaded injectable microgel system was developed and tested in a mouse model of PAD. When delivered through multiple, low volume injections, the combination of C16 and Ac

SUBMITTER: Zachman AL 

PROVIDER: S-EPMC4164579 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature