Discriminating between lysine sumoylation and lysine acetylation using mRMR feature selection and analysis.

ABSTRACT: Post-translational modifications (PTMs) are crucial steps in protein synthesis and are important factors contributing to protein diversity. PTMs play important roles in the regulation of gene expression, protein stability and metabolism. Lysine residues in protein sequences have been found to be targeted for both types of PTMs: sumoylations and acetylations; however, each PTM has a different cellular role. As experimental approaches are often laborious and time consuming, it is challenging to distinguish the two types of PTMs on lysine residues using computational methods. In this study, we developed a method to discriminate between sumoylated lysine residues and acetylated residues. The method incorporated several features: PSSM conservation scores, amino acid factors, secondary structure

SUBMITTER: Zhang N 

PROVIDER: S-EPMC4164654 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature