Transcriptional regulation of protein complexes in yeast.

ABSTRACT:

Background

Multiprotein complexes play an essential role in many cellular processes. But our knowledge of the mechanism of their formation, regulation and lifetimes is very limited. We investigated transcriptional regulation of protein complexes in yeast using two approaches. First, known regulons, manually curated or identified by genome-wide screens, were mapped onto the components of multiprotein complexes. The complexes comprised manually curated ones and those characterized by high-throughput analyses. Second, putative regulatory sequence motifs were identified in the upstream regions of the genes involved in individual complexes and regulons were predicted on the basis of these motifs.

Results

Only a very small fraction of the analyzed complexes (5-6%) have subsets of

SUBMITTER: Simonis N 

PROVIDER: S-EPMC416469 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature