Orthologous gene-expression profiling in multi-species models: search for candidate genes.

ABSTRACT: Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

SUBMITTER: Grigoryev DN 

PROVIDER: S-EPMC416470 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature