The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes.

ABSTRACT:

Background/aims

Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular risk, such as IR and arterial stiffness, in diabetes. We investigated the role of vitamin D supplementation on cardiovascular risk in type 2 diabetes patients, including metabolic parameters, IR, and arterial stiffness.

Methods

We enrolled patients who were taking antidiabetic medications or managed their diabetes using lifestyle changes. We excluded patients who were taking vitamin D or calcium supplements. We randomized participants into the vitamin D group (cholecalciferol 2,000 IU

SUBMITTER: Ryu OH 

PROVIDER: S-EPMC4164726 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature