O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males.

ABSTRACT:

Background

Hemoglobin A1c (HbA1c) is the predominant diagnostic tool for diabetes diagnosis and progression. However, it has proven to be insensitive at pre-diabetic threshold values. O-linked-β-N-acetylglucosamine (O-GlcNAc) modification has emerged as a sensitive biomarker. The purpose of this study was to explore the sensitivity of O-GlcNAc expression as a potential marker of early metabolic dysfunction in a young adult population. Healthy, young males (18-35 y) from the Assessing Inherited Metabolic syndrome Markers in the Young study (AIMMY), were divided into low (LH,0.60) or high (HH,1.61) homeostatic model assessment of insulin resistance (HOMA-IR) cohorts.

Findings

The relationships between a panel of anthropometric, metabolic measures and whole blood global protein

SUBMITTER: Myslicki JP 

PROVIDER: S-EPMC4164748 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature