The Increased Level of Serum p53 in Hepatitis B-Associated Liver Cirrhosis.

ABSTRACT:

Background

The ability of tumour suppressor protein p53 (P53) to regulate cell cycle processes can be modulated by hepatitis B virus (HBV). While preliminary evidences indicates the involvement of protein-x of HBV (HBx) in altering p53 DNA binding, no further data have been accumulated for the significance of serum p53 in chronic hepatitis B virus infected patients.

Methods

72 non-cirrhotic and 19 cirrhotic patients infected by HBV were enrolled for the analysis in this study. Enzyme linked immunosorbent assay (ELISA) was performed to study the concentrations of serum p53 protein. The tertiary structures of HBx and P53 were docked by Z-dock and Hex servers for in-silico protein-protein interaction analysis.

Results

There was a significant association between the serum

SUBMITTER: Shahnazari P 

PROVIDER: S-EPMC4164892 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature