Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children.

ABSTRACT:

Background

Most of the peanut-sensitized children do not have clinical peanut allergy. In equivocal cases, oral food challenges (OFCs) are required. However, OFCs are laborious and not without risk; thus, a test that could accurately diagnose peanut allergy and reduce the need for OFCs is desirable.

Objective

To assess the performance of basophil activation test (BAT) as a diagnostic marker for peanut allergy.

Methods

Peanut-allergic (n = 43), peanut-sensitized but tolerant (n = 36) and non-peanut-sensitized nonallergic (n = 25) children underwent skin prick test (SPT) and specific IgE (sIgE) to peanut and its components. BAT was performed using flow cytometry, and its diagnostic performance was evaluated in relation to allergy versus tolerance to peanut and validated

SUBMITTER: Santos AF 

PROVIDER: S-EPMC4164910 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature