A simulation study on the effects of dendritic morphology on layer V prefrontal pyramidal cell firing behavior.

ABSTRACT: Pyramidal cells, the most abundant neurons in neocortex, exhibit significant structural variability across different brain areas and layers in different species. Moreover, in response to a somatic step current, these cells display a range of firing behaviors, the most common being (1) repetitive action potentials (Regular Spiking-RS), and (2) an initial cluster of 2-5 action potentials with short interspike interval (ISIs) followed by single spikes (Intrinsic Bursting-IB). A correlation between firing behavior and dendritic morphology has recently been reported. In this work we use computational modeling to investigate quantitatively the effects of the basal dendritic tree morphology on the firing behavior of 112 three-dimensional reconstructions of layer V PFC rat pyramidal cells. Particu

SUBMITTER: Psarrou M 

PROVIDER: S-EPMC4165233 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature