Ontology highlight
ABSTRACT:
SUBMITTER: Zou Q
PROVIDER: S-EPMC4165276 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zou Qiang Q Wu Bing B Xue Jia J Fan Xiaoxu X Feng Congcong C Geng Shuang S Wang Ming M Wang Bin B
European journal of immunology 20131104 1
Although Treg-cell-mediated suppression during infection or autoimmunity has been described, functions of Treg cells during highly pathogenic avian influenza virus infection remain poorly characterized. Here we found that in Foxp3-GFP transgenic mice, CD8(+) Foxp3(+) Treg cells, but not CD4(+) Foxp3(+) Treg cells, were remarkably induced during H5N1 infection. In addition to expressing CD25, the CD8(+) Foxp3(+) Treg cells showed a high level of GITR and produced IL-10. In an adoptive transfer mo ...[more]