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Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation.


ABSTRACT: Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core-shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively.

SUBMITTER: Samarajeewa S 

PROVIDER: S-EPMC4165354 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation.

Samarajeewa Sandani S   Zentay Ryan P RP   Jhurry Nema D ND   Li Ang A   Seetho Kellie K   Zou Jiong J   Wooley Karen L KL  

Chemical communications (Cambridge, England) 20140101 8


Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core-shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively. ...[more]

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