Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials.

ABSTRACT:

Objective

The latest European guidelines for the management of hemorrhagic shock suggest the use of vasopressors (norepinephrine) in order to restore an adequate mean arterial pressure when fluid resuscitation therapy fails to restore blood pressure. The administration of arginine vasopressin (AVP), or its analogue terlipressin, has been proposed as an alternative treatment in the early stages of hypovolemic shock.

Design

A meta-analysis of randomized controlled animal trials.

Participants

A total of 433 animals from 15 studies were included.

Interventions

The ability of AVP and terlipressin to reduce mortality when compared with fluid resuscitation therapy, other vasopressors (norepinephrine or epinephrine), or placebo was investigated.

Measurements and mai

SUBMITTER: Cossu AP 

PROVIDER: S-EPMC4165559 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature