Biomarkers in idiopathic pulmonary fibrosis.

ABSTRACT:

Purpose of review

This review examines the recent literature on molecular biomarkers of idiopathic pulmonary fibrosis (IPF). Specific attention is dedicated to the recent studies that identified the genes associated with IPF and the peripheral blood biomarkers that predict outcome in IPF.

Recent findings

Multiple studies attempted to identify diagnostic and predictive biomarkers in IPF. Until recently, these studies were limited in size and lacked replication, but still when taken together provided convincing evidence that changes in blood proteins (KL-6, SP-A, MMP-7, CCL-18, among others) or cells (fibrocytes and T-cell subpopulations) are indicative of the disease presence and outcome. More recently, larger studies have identified gene polymorphisms associated with IPF, as

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4165635 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature