History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study.

ABSTRACT:

Objective

To assess the effects of a history of alcohol use disorders (AUDs) on risk of severe cognitive and memory impairment in later life.

Methods

We studied the association between history of AUDs and the onset of severe cognitive and memory impairment in 6,542 middle-aged adults born 1931 through 1941 who participated in the Health and Retirement Study, a prospective nationally representative U.S. cohort. Participants were assessed at 1992 baseline and follow-up cognitive assessments were conducted biannually from 1996 through 2010. History of AUDs was identified using the three-item modified CAGE questionnaire. Cognitive outcomes were assessed using the 35-item modified Telephone Interview for Cognitive Status at last follow-up with incident severe cognitive impairment

SUBMITTER: Kuzma E 

PROVIDER: S-EPMC4165640 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature