Dataset Information

Genome-wide screening for DNA variants associated with reading and language traits.

ABSTRACT: Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading- and language-related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10(-7) for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on-going international efforts to identify genes contributing to reading and language skills.

SUBMITTER: Gialluisi A

PROVIDER: S-EPMC4165772 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Genome-wide screening for DNA variants associated with reading and language traits.

Gialluisi A A Newbury D F DF Wilcutt E G EG Olson R K RK DeFries J C JC Brandler W M WM Pennington B F BF Smith S D SD Scerri T S TS Simpson N H NH Luciano M M Evans D M DM Bates T C TC Stein J F JF Talcott J B JB Monaco A P AP Paracchini S S Francks C C Fisher S E SE

Genes, brain, and behavior 20140829 7

Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quan ...[more]

PMID: 25065397

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Dataset Information

Genome-wide screening for DNA variants associated with reading and language traits.

Publications

Genome-wide screening for DNA variants associated with reading and language traits.

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