MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura.

ABSTRACT:

Background

Due to an increased frequency of vasculitis in FMF patients, many investigators have studied MEFV mutations in patients with HSP. The aim of the study is to investigate the frequency and clinical significance of MEFV mutations in Egyptian children with Henoch-Schonlein purpura (HSP). Investigating MEFV mutations in controls may help in estimating the prevalence of MEFV mutation carrier rate in Egyptian children.

Methods

The study enrolled 90 individuals, sixty children with Henoch-Schonlein purpura (HSP), together with 30 sex-and age-matched apparently healthy controls. The entire study group was screened for 12 common MEFV mutations using a reverse hybridization assay of biotinylated PCR products.

Results

Patients with HSP had a significantly higher freque

SUBMITTER: Salah S 

PROVIDER: S-EPMC4165914 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature