Statin use and risk of liver cancer: an update meta-analysis.

ABSTRACT:

Objective

Statins are commonly prescribed cholesterol-lowering drugs. Preclinical studies suggest that statins may possess cancer preventive properties. The primary objective of this meta-analysis was to determine the association between statin use and risk of liver cancer.

Design

Meta-analysis.

Setting

International.

Participants

A comprehensive literature search of PubMed, BIOSIS Previews, Web of Science, EMBASE, EBSCO and Cochrane Library was conducted through March 2014. The effect estimate was reported as pooled relative risk (RR) with 95% CIs, using the random-effects model.

Results

A total of 12 studies (1 individual patient data analysis of 22 randomised controlled trials, 5 cohorts and 6 case-controls) were qualified for this meta-analysis, invo

SUBMITTER: Shi M 

PROVIDER: S-EPMC4166249 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature