Genetics of epilepsy: The testimony of twins in the molecular era.

ABSTRACT:

Objective

Analysis of twins with epilepsy to explore the genetic architecture of specific epilepsies, to evaluate the applicability of the 2010 International League Against Epilepsy (ILAE) organization of epilepsy syndromes, and to integrate molecular genetics with phenotypic analyses.

Methods

A total of 558 twin pairs suspected to have epilepsy were ascertained from twin registries (69%) or referral (31%). Casewise concordance estimates were calculated for epilepsy syndromes. Epilepsies were then grouped according to the 2010 ILAE organizational scheme. Molecular genetic information was utilized where applicable.

Results

Of 558 twin pairs, 418 had confirmed seizures. A total of 534 twin individuals were affected. There were higher twin concordance estimates for monoz

SUBMITTER: Vadlamudi L 

PROVIDER: S-EPMC4166361 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature