Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.

ABSTRACT: Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker p

SUBMITTER: Lacoste B 

PROVIDER: S-EPMC4166422 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature