Molecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes.

ABSTRACT:

Objective

Transcriptional profiling of epithelial ovarian cancer has revealed molecular subtypes correlating to biological and clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and investigate similarities with the well-established intrinsic molecular subtypes of breast cancer.

Methods

Global gene expression profiling using Illumina's HT12 Bead Arrays was applied to 59 fresh-frozen serous ovarian malignant, benign and borderline tumors. Nearest centroid classification was performed applying previously published gene profiles for the ovarian and breast cancer subtypes. Correlations to gene expression modules representing key biological breast cancer features were also sought. Validation was per

SUBMITTER: Jonsson JM 

PROVIDER: S-EPMC4166462 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature