Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.

ABSTRACT:

Context

Second-generation antipsychotics (SGAs) are increasingly used in the treatment of many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk.

Objective

To identify single-nucleotide polymorphisms associated with antipsychotic drug–induced weight gain.

Design

Pharmacogenetic association study.

Setting

The discovery cohort was from a US general psychiatric hospital. Three additional cohorts were from psychiatric hospitals in the United States and Germany and from a European antipsychotic drug trial.

Participants

The discovery cohort consisted of 139 pediatric patients undergoing first exposure to SGAs. The 3 additional cohorts consist

SUBMITTER: Malhotra AK 

PROVIDER: S-EPMC4166499 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature