Peripheral inflammation acutely impairs human spatial memory via actions on medial temporal lobe glucose metabolism.

ABSTRACT:

Background

Inflammation impairs cognitive performance and is implicated in the progression of neurodegenerative disorders. Rodent studies demonstrated key roles for inflammatory mediators in many processes critical to memory, including long-term potentiation, synaptic plasticity, and neurogenesis. They also demonstrated functional impairment of medial temporal lobe (MTL) structures by systemic inflammation. However, human data to support this position are limited.

Methods

Sequential fluorodeoxyglucose positron emission tomography together with experimentally induced inflammation was used to investigate effects of a systemic inflammatory challenge on human MTL function. Fluorodeoxyglucose positron emission tomography scanning was performed in 20 healthy participants before an

SUBMITTER: Harrison NA 

PROVIDER: S-EPMC4166523 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature