Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury.

ABSTRACT:

Objectives

Severe thermal injury is associated with extreme and prolonged inflammatory and hypermetabolic responses, resulting in significant catabolism that delays recovery or even leads to multiple organ failure and death. Burned patients exhibit many symptoms of stress-induced diabetes, including hyperglycemia, hyperinsulinemia, and hyperlipidemia. Recently, the nucleotide-binding domain, leucine-rich family (NLR), pyrin-containing 3 (NLRP3) inflammasome has received much attention as the sensor of endogenous "danger signals" and mediator of "sterile inflammation" in type II diabetes. Therefore, we investigated whether the NLRP3 inflammasome is activated in the adipose tissue of burned patients, as we hypothesize that, similar to the scenario observed in chronic diabetes, the cy

SUBMITTER: Stanojcic M 

PROVIDER: S-EPMC4166573 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature