Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia.

ABSTRACT:

Background

Population pharmacokinetic (popPK) models derived from small pharmacokinetics (PK) studies in neonates are often underpowered to detect clinically important characteristics that drive dosing. External validation of such models is crucial. In this study, the predictive performance of a gentamicin popPK model in neonates receiving hypothermia was evaluated.

Methods

A previously published gentamicin popPK model was developed in neonates with hypoxic ischemic encephalopathy undergoing hypothermia using a retrospective single-institution (University of California-San Francisco) data set. The predictive performance of this model was evaluated in an external retrospective data set from the University of California-San Francisco (validation A) and another from Duke Univer

SUBMITTER: Sampson MR 

PROVIDER: S-EPMC4166612 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature