Hypoactivity affects IGF-1 level and PI3K/AKT signaling pathway in cerebral structures implied in motor control.

ABSTRACT: A chronic reduction in neuromuscular activity through prolonged body immobilization in human alters motor task performance through a combination of peripheral and central factors. Studies performed in a rat model of sensorimotor restriction have shown functional and biochemical changes in sensorimotor cortex. However, the underlying mechanisms are still unclear. Interest was turned towards a possible implication of Insulin-like Growth Factor 1 (IGF-1), a growth factor known to mediate neuronal excitability and synaptic plasticity by inducing phosphorylation cascades which include the PI3K-AKT pathway. In order to better understand the influence of IGF-1 in cortical plasticity in rats submitted to a sensorimotor restriction, we analyzed the effect of hindlimb unloading on IGF-1 and its main

SUBMITTER: Mysoet J 

PROVIDER: S-EPMC4166665 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature