TDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine.

ABSTRACT:

Objective

We investigated in a sham-controlled trial the analgesic effects of a 4-week treatment of transcranial direct current stimulation (tDCS) over the primary motor cortex in chronic migraine. In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation.

Methods

Thirteen patients with chronic migraine were randomized to receive 10 sessions of active or sham tDCS for 20 minutes with 2 mA over 4 weeks. Data were collected during baseline, treatment and follow-up. For the tDCS computational analysis, we adapted a high-resolution individualized model incorporating accurate segmentation of cortical and subcortical structures of interest.

Results

There w

SUBMITTER: Dasilva AF 

PROVIDER: S-EPMC4166674 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature