Breast Cancer Risk - Genes, Environment and Clinics.

ABSTRACT: The information available about breast cancer risk factors has increased dramatically during the last 10 years. In particular, studies of low-penetrance genes and mammographic density have improved our understanding of breast cancer risk. In addition, initial steps have been taken in investigating interactions between genes and environmental factors. This review concerns with actual data on this topic. Several genome-wide association studies (GWASs) with a case-control design, as well as large-scale validation studies, have identified and validated more than a dozen single nucleotide polymorphisms (SNPs) associated with breast cancer risk. They are located not only in or close to genes known to be involved in cancer pathogenesis, but also in genes not previously associated with breast canc

SUBMITTER: Fasching PA 

PROVIDER: S-EPMC4166916 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature