Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

ABSTRACT: Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both adjacent to and distant from the tumor site. This DNA damage was dependent on CCL2, a cytokine involved in the recruitment and activation of macrophages, suggesting that this systemic DNA damage was mediated via tumor-induced chronic inflammatory responses involving cytokines, activation of macrophages, and consequent free radical production. If free radicals are involved, then a diet containing an antioxidant may decrease the distant DNA damage. Here we repeated our standard protocol in cohorts of two syngeneic tumor-bearing C57BL/6NCr mice t

SUBMITTER: Georgakilas AG 

PROVIDER: S-EPMC4167057 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature