Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases.

ABSTRACT:

Introduction

Neurodegenerative diseases share common pathologic features including neuroinflammation, mitochondrial dysfunction and protein aggregation, suggesting common underlying mechanisms of neurodegeneration. We undertook a meta-analysis of public gene expression data for neurodegenerative diseases to identify a common transcriptional signature of neurodegeneration.

Results

Using 1,270 post-mortem central nervous system tissue samples from 13 patient cohorts covering four neurodegenerative diseases, we identified 243 differentially expressed genes, which were similarly dysregulated in 15 additional patient cohorts of 205 samples including seven neurodegenerative diseases. This gene signature correlated with histologic disease severity. Metallothioneins featured promine

SUBMITTER: Li MD 

PROVIDER: S-EPMC4167139 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature